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ECS

The ECS.  The endocannabinoid system, a buzzword in this new era of cannabis.  In the last Notes posting, we touched on the ECS briefly. Let us dive a bit deeper into the essence of what it is.  There is a significant amount of information available around the ECS and how cannabis interacts with it… let’s dive deeper.  

In general, there are two known cannabinoid receptors in the ECS.  These are the CB1 and CB2. CB1 receptors are mainly found in the CNS (central nervous system).  CB2 receptors are mainly found in the PNS (peripheral nervous system) and immune systems. There are several different cannabinoid classes, but we will only highlight two of them here: endocannabinoids and phytocannabinoids.  Endocannabinoids (anadamide, 2-AG) are produced endogenously (within the body) and function within the ECS. Phytocannabinoids (THC and CBD) are produced by the plant, Cannabis sativa, and also function within the ECS, plus a multitude of other physiological systems.

The ECS operates through a mechanism called retrograde signalling.  This is a fairly unique mode of communication in the human body. Only a few physiological processes use this method of signalling.  It is, however, fascinating. In short, the ECS functions as a feedback loop, sending information “upstream” to help modulate or control the ensuing “downstream” processes.  Through this mechanism the ECS is able to help bring the body into homeostasis or a balanced state.

The ECS is phylogenetically ancient.  It evolved around 600 million years ago.  It is present in every animal on the planet, except for insects.  In humans, the ECS touches on many foundational physiological systems: reproductive, immune, nervous, pulmonary, and digestive to name a few.  Look for future posts in which we will try and tease out the nuance of this amazing, complicated, and awe inspiring system. We hope you that you come to to be love the ECS as much as we do.  Enjoy.

Additional reading:

Check out Leafly’s overview of the ECS for a deeper look into how it works, how cannabis and cannabinoids interact within your ECS, and where the story of Goldilocks and the Three Bears fits into all of this.

Want to go even deeper? Click here for a physician’s overview of the ECS.

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Protab

Cannabis is a journey of discovery, and a core tenet of LEVEL is to create unique formulations that help facilitate your goals and desired effects. Whether that’s managing chronic pain, relieving anxiety, spurring creativity or reaching an elevated social state, the scope of our products are designed to reach anyone from a novice microdoser to those seeking high-dose solutions. Because our bodies and our experiences with cannabis are so individual and unique, our product line reflects that. Keeping the multi-faceted needs of a consumer, we are proud to introduce the Protab to the LEVEL family. The Protab is a 25mg oral tablet, infused with steam distilled cannabis terpenoids. It is available in seven unique formulations: Delta-9 THC, Delta-8 THC, THCA, CBD and CBG.


The Protab is scored so that you can split the tablet into two 12.5mg doses for your custom needs. The Protab typically dissolves in the stomach in sixty seconds or less with onset time within thirty minutes. This product is designed for those seeking an extra strength, yet precise and standardized dose for a controlled experience. Find all our Protab formulations here!

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Cannabis

Cannabis contains a variety of chemical compounds that are responsible for the unique characteristics of the plant – cannabinoids, terpenoids, and flavonoids. Terpenoids are responsible for the organoleptic (flavor and aroma profiles) character, as well as used to differentiate between strain types. Terpenoids are also responsible for the different physiological effects experienced when using Sativa, Hybrid, or Indica.  Flavonoids are compounds that are ubiquitous in nature, found in parsley, blueberries, and black tea, and provide not only color but therapeutic benefit such as anti-inflammatory properties.

For LEVEL, the key to unique formulation lies within cannabinoids. Most individuals are only familiar with delta-9 THC and/or CBD, but this is just the start of this powerful class of compounds.  There are 11 different classes of cannabinoids comprised of more than sixty-five unique molecules. Cannabinoids act in the body through the ECS or EndoCannabinoid System.  Not only is the ECS phylogenetically ancient (it has been evolving in animals for more than 600 million years), it holds the keys to understanding how and why cannabis has such profound impact on various human conditions.  

This fascinating and amazing physiological system  is comprised of two different receptor types, CB1 and CB2.  CB1 receptors are mainly found in the CNS (central nervous system) and CB2 receptors are located in the PNS (peripheral nervous system).  The interaction between cannabinoids and the ECS is what produces the wide range of effects experienced when consuming cannabis. These feelings can range from feeling high (with delta-9 THC) or experiencing the anti-inflammatory benefits of CBD.

Click here for Merry Jane’s deep look into the world of Flavonoids, how they contribute to the overall sensory experience , and why flavonoid research still remains an understudied. 

Leafly’s overview of Terpenoids will walk you through what they do and how they affect your cannabis experience.  

Want to go even deeper? Check out this article from the British Journal of Pharmacology.