Posted on

The human ECS system and cannabis are made for each other



We have special receptors throughout our bodies that cannabinoids like THC and CBD can “plug” into.


D.A.R.E. teachers and straight-edge legislators might find this alarming, but our bodies naturally produce molecules that are quite similar to those found in cannabis. Take a moment to let that sink in. Your body, right now, is likely producing something very similar to a federally illegal substance.

When scientists named these cannabis-like molecules “endocannabinoids,” they didn’t exactly do us any favors. The label doesn’t roll off the tongue or evoke the sense of awe we should probably reserve for this coincidence. But thanks to cannabis, researchers were able to unlock a new layer of understanding about how we feel pain, make memories, metabolize food, boost our immune systems, and maintain other essential functions. It all started with researchers trying to understand how we’re able to feel that classic cannabis high. In the process, they discovered we have special receptors throughout our bodies that cannabinoids like THC can “plug” into.


How do we know this to be true?


The year is 1990. The Berlin wall is coming down. The Fresh Prince of Bel-Air premieres. Molecular biologist Lisa Matsuda proves the human body’s cannabinoid receptors allow us to get high. How she’s able to do this is quite remarkable. Building off of Dr. Allyn Howlett’s discovery of CB1 receptors in 1988, Matsuda and her team were able to decode the DNA of a CB1 receptor and use that code to clone another receptor. With that knowledge, they were able to genetically engineer a mouse to lack this receptor. They then administered THC to this bioengineered mouse. And when the THC failed to get the mouse stoned, they effectively proved the receptor’s purpose.

Up until that point, there’d only been anecdotal evidence that cannabis could reroute mind body communications. Despite evolving alongside cannabis for thousands of years, we humans knew little about it all worked. The discovery of cannabis receptors didn’t just reveal the system our bodies use to interact with the plant; it gave scientists a window into the complex signaling systems used to regulate a range of functions and help our bodies achieve balance. The endocannabinoid system (ECS) may have been named after the plant that led to its discovery, but it does much more—most of which we have yet to explore.

So, we make cannabis-like molecules of our own, but what happens when you add actual cannabinoids (and phytocannabinoids) to the mix? Put simply, cannabinoids act like traffic conductors in your body, blocking some signals from passing (like pain) while moving others along (like appetite). Our bodies naturally do this all the time, but adding cannabinoids is akin to putting really enthusiastic crossing guards on every corner. Early research shows endocannabinoid deficiencies may be at the root of issues like fibromyalgia, migraines, and irritable bowel syndrome. So for those who don’t make enough endocannabinoids on their own, introducing cannabinoids may help restore order. All of our endocannabinoid systems are different, so in this regard, slow and steady experimentation is key.

Plenty of drugs have natural origins. But unlike morphine, which involves concentrating massive quantities of opium poppy, or tequila, which involves roasting, mashing, and rotting the sugary centers of agave plants, cannabis is unique in that we don’t need to do much to it to feel its effects. Knowing this, it’s easy to see why cannabis presents some big opportunities because the benefits we get from THC and CBD are both abundant and readily available. Still, it’s worth remembering the fan-favorite, THC, is merely one among dozens of distinct cannabinoids that have been found in the plant so far. We’re familiar with THC and CBD because they occur in much higher percentages than their less-famous cousins (like THCV, CBG, and Delta-8 THC, or the acidics), but they only represent the surface of what we have yet to discover.

So, what happens if we decide to treat those lesser-known cannabinoids with the same attention given to other plants? There’s a good chance we could stumble upon unknown benefits — perhaps even a new way of relating to our bodies altogether.





New to cannabis? Try a LEVEL 3 mg low-dose Tablingual.


The Tablingual is a 3 mg micro-dose sublingual tablet that is dissolved under the tongue. The tablet will dissolve within a minute or so. Feel free to bite it in half if it’s not dissolving quickly and increase dosage as desired. Takes effect in approximately 5-20 minutes. Experience effects for 1-2 hours. Try different combinations to find your perfect blend and dose.



Posted on



LEVEL CBN is designed to promote sleep

CBN is a mildly psychoactive cannabinoid that is formed as a result of the degradation of THC. CBN is often described as a mild analgesic, with many reporting a relaxing and sedating effect.



CBN Explained

If you’ve ever smoked flower well past its prime only to find it made you sleepy, congratulations. You have experienced the sedating powers of cannabinol (CBN). In fact, the more potent the flower was when you originally bought it, the more likely it is to make you pass out after you rediscover it in your sock drawer months or years later. The reason for this is simple. THC, the psychoactive cannabinoid we all know and love, gradually converts into the sleepy, not-so-psychoactive cannabinoid CBN as it oxidizes and ages. Just when you thought geriatric cannabis had nothing to offer.

Despite not being as well known as THC or CBD, CBN has been crucial to our scientific understanding of the plant. It’s the first cannabinoid scientists isolated in their quest to understand how cannabis affects us, and early research shows it may have promise as an analgesic, or pain reliever. CBN even led to the discovery of cannabis use in ancient China. Archaeologists determined the 2,500-year-old herb was particularly potent because the charred remnants contained high levels of CBN.

Thankfully, you don’t need to age flower for thousands of years to reap the benefits of CBN. Scientifically formulated to help with sleep, the LEVEL CBN Tablingual is designed to dissolve under your tongue so that you can feel the effects in 30 minutes or less. Keep in mind that the key to experimenting with any new cannabinoid is to take it low and slow. Start with the lowest dose possible, and increase your intake gradually until you find the perfect amount for you. Once you understand how your body reacts, you can further experiment by pairing CBN with other cannabinoids to maximize the sleep-inducing, pain-relieving benefits. With LEVEL, you can be your own expert.



Posted on





Fresh Minty Flavor
Sugar Free
Gluten Free
Xylitol Sweetened for Oral Health
Cannabis-Only Terpenoids



10 pieces
10 mg CBD per piece
0 mg THC
100 mg CBD per package



10 pieces
10 mg THC per piece
1 mg CBD per piece
100 mg THC per package
10 mg CBD per package



10 pieces
4 mg THCV per piece
1 mg CBG per piece
0 mg THC
0 mg CBD
40 mg THCV per package
10 mg CBG per package




Posted on

LEVEL sits down with Investing in Cannabis

LEVEL Founder Chris Emerson, Ph.D. recently sat down with Brandon David, host of the Investing in Cannabis podcast, where they discussed unique and rare cannabinoids in isolation and concentration, experiencing the landscape and growth as a cannabis business first-hand, and more.
Click to listen for a great dialogue and insight into the constant evolution of the cannabis industry.


Posted on

Discover What’s in the Cannabis You’re Consuming


Certificate of Analysis (COA) provides useful information about the cannabis products you consume.

Do you read the nutrition and ingredient information on food packaging at grocery stores? For most of us, the answer is YES, all the time. Whether motivated by health, allergies, or just plain curiosity, the modern consumer has taken a keen interest in reading food labels.

Similar to the nutrition and ingredient information on food products, every licensed cannabis product has to be tested at a state-approved lab and is then given a Certificate of Analysis (COA) which provides useful information about the product’s potency and cannabinoid and terpenoid profiles. The analysis also screens for pesticides, microbes, heavy metals, and more. COAs help you understand exactly what is in the cannabis product you’re buying, which not only keeps you safe but also helps you better understand whether a product might be right (or wrong) for you.



At LEVEL, we take pride in delivering safe, consistent cannabis products that result in the same great experience every time. We set the industry standard for consistency, purity, and predictable desired effects. Find the COAs for every LEVEL product here, listed by the batch number on the label.

Knowledge is power. Educate yourself. If you have any questions, please reach out at

Posted on

This Guy Wants To Hack Your High With Rare Cannabinoids

“If THC and CBD are the salt and pepper of weed, rare cannabinoids are everything else. LEVEL’s Chris Emerson, Ph.D. explains why you should try them all.”



Check out Proper’s feature on LEVEL Chief Scientist Chris Emerson Ph.D., and his approach and methodology for diving deeper into unique and rare cannabinoids.

“At a time when just about everyone set their sights on increasing THC levels (often at the cost of other cannabinoids), Emerson and his team realized you could only do so much with this approach. “We hypothesized we wouldn’t be able to get to unique or different effects from cannabis if we were playing with the same cannabinoids,” he said. To put this into perspective, imagine a world in which chefs season their food with only salt and pepper. Would you still expect to have a wildly different experience from one restaurant to another? In reality, chefs have hundreds of spices at their disposal, some of which are easier to access than others. Similarly, cannabis plants produce more than 65 known cannabinoids, THC and CBD being the most abundant.”



Posted on


To our community –

We develop our products for humans. Humans seeking pain relief, humans seeking tools to aid in anxiety and stress. Humans experiencing chronic conditions, or humans simply seeking pleasure, relaxation, maybe a boost of energy to get through the day.

There are a multitude of things that make all of us different, unique and special. But at the fundamental level – we are all human.

As a San Francisco company, we are extremely proud of the work our city and community does to celebrate Pride – to celebrate humans, love, to be ourselves, and love who we want. To honor the qualities that make each of us one of a kind, and to protect the rights that we all deserve equally.

Wherever you are, thank you for being YOU. Happy Pride from our HQ in San Francisco, CA.

– The LEVEL family

Posted on

Have a question about the Pod? We’re here to help.

Where do you start with a LEVEL Pod? How many uses per Pod? What’s the onset time? Our products are formulated for targeted effects and reliable outcomes – the LEVEL Pod is no exception. If you’re new to PAX Era, or Pods in general, don’t hesitate, we’re here to help.

You can reach us by replying to this email. You can also find us at or on instagram.